3. Nutrition & Healthy Eating

An investigation of the effects of lutein and zeaxanthin supplementation on inflammatory markers, oxidative stress and age related macular degeneration risk

Project Reference:

03-PG-006

Status:

Completed

Commencement Date:

October, 2003

Project Duration:

36 months

Abstract:

Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in industrialised countries. This project aimed to assess whether the carotenoids, lutein and zeaxanthin, in comparison to beta-carotene, exert effects on inflammatory markers and oxidative stress that may influence AMD development.

A randomised, double blind, placebo-controlled study in which smokers and non-smokers receive dietary supplements of lutein and zeaxanthin was carried out and various indicators of inflammatory status were monitored over a two-month period. A further study examined delivery of these carotenoids using food supplements (carrot juice for carotene and dried spinach powder for lutein and zeaxanthin).

Principal Contractor(s):

Dr Jayne Woodside, Queen’s University Belfast

Collaborator(s):

Single supplier

Outputs:

Report:

The PhD thesis is available on request and can be accessed through Queen’s University Belfast