3. Nutrition & Healthy Eating

An investigation of the effects of lutein and zeaxanthin supplementation on inflammatory markers, oxidative stress and age related macular degeneration risk

Project Reference:




Commencement Date:

October, 2003

Project Duration:

36 months


Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in industrialised countries. This project aimed to assess whether the carotenoids, lutein and zeaxanthin, in comparison to beta-carotene, exert effects on inflammatory markers and oxidative stress that may influence AMD development.

A randomised, double blind, placebo-controlled study in which smokers and non-smokers receive dietary supplements of lutein and zeaxanthin was carried out and various indicators of inflammatory status were monitored over a two-month period. A further study examined delivery of these carotenoids using food supplements (carrot juice for carotene and dried spinach powder for lutein and zeaxanthin).

Principal Contractor(s):

Dr Jayne Woodside, Queen’s University Belfast


Single supplier



The PhD thesis is available on request and can be accessed through Queen’s University Belfast